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I'm (wildly) guessing that once the mouth joint is added, a custom motion would have to be generated with the (new?) motion editor. so the questions you are asking here are, "can we add a custom joint to a model?", and "can we create a motion for it?", I guess.
I'm pretty sure the list of joints Dark recognizes is hardcoded/non-editable, but not sure whether this would actually pose a problem.
And I cannot imagine this working for hybrids without unintentional comedy.
It seems System Shock 2 doesn't use conventional joints, but an archaic system of boxes and planes.